Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen

Naked mole-rat

It’s a mammal Jim, but not as we know it... Mammals are typically characterised as furry and warmblooded. The naked mole-rat is neither of these. Being underground and surrounded by hundreds of brothers and sisters, there is little fluctuation in surrounding temperature and they have all but lost the ability to regulate their body temperature physiologically. Living in the dark, they can no lon...

Genome Stability Maintenance in Naked Mole-Rat

The naked mole-rat (Heterocephalus glaber) is one of the most promising models used to study genome maintenance systems, including the effective repair of damage to DNA. The naked mole-rat is the longest lived rodent species, which is extraordinarily resistant to cancer and has a number of other unique phenotypic traits. For at least 80% of its lifespan, this animal shows no signs of aging or a...

Extreme Resistance to Oxygen Deprivation in Brain Tissue from the Naked Mole-Rat BY BETHANY

The naked mole rat genome: understanding aging through genome analysis

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Functional Characteristics of the Naked Mole Rat μ-Opioid Receptor

While humans and most animals respond to µ-opioid receptor (MOR) agonists with analgesia and decreased aggression, in the naked mole rat (NMR) opioids induce hyperalgesia and severe aggression. Single nucleotide polymorphisms in the human mu-opioid receptor gene (OPRM1) can underlie altered behavioral responses to opioids. Therefore, we hypothesized that the primary structure of the NMR MOR may...